For complete list:
2025
Green NC, Gao H, Chu X, Yuan Q, McGuire P, Lai D, Jiang G, Xuei X, Reiter JL, Stevens J, Sutherland GT, Goate AM, Pang ZP, Slesinger PA, Hart RP, Tischfield JA, Agrawal A, Wang Y, Duren Z, Edenberg HJ, Liu Y. Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. Nat Commun. 2025 Oct 13;16(1):9070. doi: 10.1038/s41467-025-64136-0. PMID: 41083468; PMCID: PMC12518533.
Li X, Hart RP, Pang ZP. Beyond the synapse: Bassoon mutations drive epilepsy through Astrocyte-Neuron crosstalk. Neurotherapeutics. 2025 Sep 30:e00753. doi: 10.1016/j.neurot.2025.e00753. Epub ahead of print. PMID: 41033923.
Su X, Zhang H, Hong Y, Yang Q, Wang L, Le T, Liu J, Cheruvu L, Labour E, Zhang S, Mendez-Maldonado K, Kreimer A, Song H, Ming GL, Duan J, Pang ZP. Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons. Mol Psychiatry. 2025 Sep 17. doi: 10.1038/s41380-025-03246-z. Epub ahead of print. PMID: 40962831.
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Byeon SK, Thapa C, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Schneider JA, Pandey A, Bennett DA, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J. PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia. Nature. 2025 Sep 3. doi: 10.1038/s41586-025-09486-x. Epub ahead of print. PMID: 40903578.
Boreland AJ, Abbo Y, Li X, Stillitano AC, Zhang S, Duan J, Pang ZP, Hart RP. Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model. Alcohol (in press) bioRxiv [Preprint]. 2025 Aug 6:2025.08.04.668469. doi: 10.1101/2025.08.04.668469. PMID: 40799555; PMCID: PMC12340822.
English J, McSweeney D, Geng J, Howell E, Ribbe F, Hinderhofer M, Proskauer L, Sebastian R, Wang L, Sharf T, Pang ZP, Pak C. Distinct Synaptic Mechanisms Drive NRXN1 Variant-Mediated Pathogenesis in iPSC-Derived Neuronal Models of Autism and Schizophrenia. bioRxiv [Preprint]. 2025 Jul 19:2025.07.18.664735. doi: 10.1101/2025.07.18.664735. PMID: 40791539; PMCID: PMC12338733.
Wang L, Savani R, Bernabucci M, Lu Y, Singh I, Xu W, El Ouaamari A, Wheeler MB, Grill HJ, Rossi MA, Pang ZP. State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis. Nature Metabolism 2025 Jun 4. doi: 10.1038/s42255-025-01305-x. Online ahead of print. PMID: 40467923
Zhao X, Li Y, Zhang S, Sudwarts A, Zhang H, Kozlova A, Moulton MJ, Goodman LD, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication. Molecular Neurodegeneration 2025 May 3;20(1):51. doi: 10.1186/s13024-025-00840-1. PMID: 40319306
Lee YK, Xiao C, Zhou X, Wang L, McReynolds MG, Wu Z, Purisic E, Kim H, Li X, Pang ZP, Dai J, Peng J, Yang N, Yue Z. Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission. bioRxiv [Preprint]. 2025 Jan 29:2024.12.30.630813. doi: 10.1101/2024.12.30.630813.PMID: 39803523
Lkhagvasuren B, Pang ZP, Jadamba T, Hiramoto T, Cheslack-Postava K, Musa GJ, Hoven CW, Sudo N. Obesity and its associations with autonomic and cognitive functions in the general population. PLoS One. 2025 May 8;20(5):e0322802. doi: 10.1371/journal.pone.0322802. eCollection 2025., PMID: 40341659
Liang L, Zhang S, Wang Z, Zhang H, Li C, Duhe AC, Sun X, Zhong X, Kozlova A, Jamison B, Wood W, Pang ZP, Sanders AR, He X, Duan J. Single-cell multiomics of neuronal activation reveals context-dependent genetic control of brain disorders. bioRxiv [Preprint]. 2025 Feb 17:2025.02.17.638682. doi: 10.1101/2025.02.17.638682.PMID: 40027724
Wang H, Hoffmann C, Tromm JV, Su X, Elliott J, Wang H, Baum J, Pang ZP, Milovanovic D, Shi Z. Live-Cell Quantification Reveals Viscoelastic Regulation of Synapsin Condensates by α-Synuclein. Science Advances, 2025 Apr 18;11(16):eads7627. doi: 10.1126/sciadv.ads7627. Epub 2025 Apr 18. PMID: 40249817
2024
Li X, Liu J, Boreland AJ, Kapadia S, Zhang S, Stillitano AC, Abbo Y, Clark L, Lai D, Liu Y, Barr PB, Meyers JL, Kamarajan C, Kuang W, Agrawal A, Slesinger PA, Dick D, Salvatore J, Tischfield J, Duan J, Edenberg HJ, Kreimer A, Hart RP, Pang ZP. Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell Model. Science Advances. 2024 Nov 8;10(45):eado5820. doi: 10.1126/sciadv.ado5820. Epub 2024 Nov 8. PMID: 39514655
Tahiri A, Youssef A, Inoue R, Moon S, Alsarkhi L, Berroug L, Nguyen XTA, Wang L, Kwon H, Pang ZP, Zhao JY, Shirakawa J, Ulloa L and El Ouaamari A Vagal Sensory Neuron-Derived FGF3 Controls Insulin Secretion. Developmental Cell 2024 Oct 15:S1534-5807(24)00542-2. doi: 10.1016/j.devcel.2024.09.016
Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J. Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microglia. Res Sq . 2024 May 24:rs.3.rs-4407146. doi: 10.21203/rs.3.rs-4407146/v1. PMID: 38826437. Preprint
Caiola HO, Wu Q, Soni S, Wang XF, Monahan K, Pang ZP, Wagner GC, Zhang H. Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2. FASEB Journal, 2024 Oct 31;38(20):e70124. doi: 10.1096/fj.202400454R
Zhang H,, McCarroll A, Peyton L, de León Guerrerro SD, Zhang S, Gowda P, Sirkin D, El Achwah M, Duhe A, Wood WG, Jamison B, Tracy G, Pollak R, Hart RP, Pato CN, Mulle JG, Sanders AR, Pang ZP, Duan J. Scaled and Efficient Derivation of Loss of Function Alleles in Risk Genes for Neurodevelopmental and Psychiatric Disorders in Human iPSC. Stem Cell Reports. 2024 Sep https://doi.org/10.1016/j.stemcr.2024.08.003.
Voglewede MM, Ozsen EN, Ivak N, Bernabucci M, Tang R, Sun M, Pang ZP, Zhang H. Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory. iScience. 2024 Jun 19;27(7):110308. doi: 10.1016/j.isci.2024.110308. eCollection 2024 Jul 19. PMID: 39045101
Lu Y, Wang L, Luo F, Savani R, Rossi MA, Pang ZP. Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections. Molecular Metabolism. 2024 May 17; 85:101960. doi: 10.1016/j.molmet.2024.101960. PMID: 38763494
Boreland AJ, Stillitano AC, Lin HC, Abbo Y, Hart RP, Jiang P, Pang ZP, Rabson AB. Sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids. iScience. 2024 Mar 28;27(5):109628. doi: 10.1016/j.isci.2024.109628. eCollection 2024 May 17. PMID: 38628961
Prytkova I, Liu Y, Fernando M, Gameiro-Ros I, Popova D, Kamarajan C, Xuei X, Chorlian DB, Edenberg HJ, Tischfield JA, Porjesz B, Pang ZP, Hart RP, Goate A, Slesinger PA.
Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons. J Neurosci. 2024 Apr 17;44(16):e0918232024. doi: 10.1523/JNEUROSCI.0918-23.2024. PMID: 38350999
Savani R, Park E, Busannagari N, Lu Y, Kwon H, Wang L, Pang ZP. Metabolic and behavioral alterations associated with viral vector-mediated toxicity in the paraventricular hypothalamic nucleus. Biosci Rep. 2024 Jan 16;44(1):BSR20231846. doi: 10.1042/BSR20231846..PMID: 38227343
2023
Rich MT, Worobey SJ, Mankame S, Pang ZP, Swinford-Jackson SE, Pierce RC. Sex-dependent fear memory impairment in cocaine-sired rat offspring. Sci Adv. 2023 Oct 20;9(42):eadf6039. doi: 10.1126/sciadv.adf6039. Epub 2023 Oct 18.PMID: 37851809
Siwei Zhang, Hanwen Zhang, Marc P Forrest, Yifan Zhou, Xiaotong Sun, Vikram A Bagchi, Alena Kozlova, Marc Dos Santos, Nicolas H Piguel, Leonardo E Dionisio, Alan R Sanders, Zhiping P Pang, Xin He, Peter Penzes, Jubao Duan. Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons. Cell Genomics. 2023 Aug 28. https://doi.org/10.1016/j.xgen.2023.100399
Gameiro-Ros I, Popova D, Prytkova I, Pang ZP, Liu Y, Dick D, Bucholz KK, Agrawal A, Porjesz B, Goate AM, Xuei X, Kamarajan C; COGA Collaborators; Tischfield JA, Edenberg HJ, Slesinger PA, Hart RP. 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics. Genes Brain Behav. 2023 Aug 2:e12855. doi: 10.1111/gbb.12855. Online ahead of print. PMID: 37533187
Gabriel R 3rd, Boreland AJ, Pang ZP. Whole Cell Patch Clamp Electrophysiology in Human Neuronal Cells. Methods Mol Biol. 2023;2683:259-273. doi: 10.1007/978-1-0716-3287-1_21. PMID: 37300782
2022
Singh I, Wang L, Xia B, Liu J, Tahiri A, El Ouaamari A, Wheeler MB, Pang ZP. Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake. Cell Biosci. 2022 Oct 29;12(1):178. doi: 10.1186/s13578-022-00914-3.PMID: 36309763
Wang L, Mirabella VR, Dai R, Su X, Xu R, Jadali A, Bernabucci M, Singh I, Chen Y, Tian J, Jiang P, Kwan KY, Pak C, Liu C, Comoletti D, Hart RP, Chen C, Südhof TC, Pang ZP. Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism. Mol Psychiatry. 2022 Oct 24. doi: 10.1038/s41380-022-01834-x. Online ahead of print.PMID: 36280753
McSweeney D, Gabriel R, Jin K, Pang ZP, Aronow B, Pak C. CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons. iScience. 2022 Sep 23;25(10):105187. doi: 10.1016/j.isci.2022.105187. eCollection 2022 Oct 21.PMID: 36262316
Popova D, Gameiro-Ros I, Youssef MM, Zalamea P, Morris AD, Prytkova I, Jadali A, Kwan KY, Kamarajan C, Salvatore JE, Xuei X, Chorlian DB, Porjesz B, Kuperman S, Dick DM, Goate A, Edenberg HJ, Tischfield JA, Pang ZP, Slesinger PA, Hart RP. Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. Mol Psychiatry. 2022 Oct 7:1-13. doi: 10.1038/s41380-022-01818-x. Online ahead of print.PMID: 36207584
Zhao N, Francis NL, Song S, Kholodovych V, Calvelli HR, Hoop CL, Pang ZP, Baum J, Uhrich KE, Moghe PV. CD36-Binding Amphiphilic Nanoparticles for Attenuation of Alpha Synuclein-Induced Microglial Activation. Adv Nanobiomed Res. 2022 Jun;2(6):2100120. doi: 10.1002/anbr.202100120. Epub 2022 Mar 22. PMID: 36051821
Kozlova A, Zhang S, Kotlar AV, Jamison B, Zhang H, Shi S, Forrest MP, McDaid J, Cutler DJ, Epstein MP, Zwick ME, Pang ZP, Sanders AR, Warren ST, Gejman PV, Mulle JG, Duan J. Loss of function of OTUD7A in the schizophrenia- associated 15q13.3 deletion impairs synapse development and function in human neurons. Am J Hum Genet. 2022 Aug 4;109(8):1500-1519. doi: 10.1016/j.ajhg.2022.07.001.PMID: 35931052
Connacher R, Williams M, Prem S, Yeung PL, Matteson P, Mehta M, Markov A, Peng C, Zhou X, McDermott CR, Pang ZP, Flax J, Brzustowicz L, Lu CW, Millonig JH, DiCicco-Bloom E. Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses. Stem Cell Reports. 2022 Jun 14;17(6):1380-1394. doi: 10.1016/j.stemcr.2022.04.019. Epub 2022 May 26.
PMID: 35623351
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease. Cell Stem Cell. 2022 Jul 7;29(7):1135-1153.e8. doi: 10.1016/j.stem.2022.06.007.PMID: 35803230
Guvenek A, Shin J, De Filippis L, Zheng D, Wang W, Pang ZP, Tian B. Neuronal Cells Display Distinct Stability Controls of Alternative Polyadenylation mRNA Isoforms, Long Non-Coding RNAs, and Mitochondrial RNAs. Front Genet. 2022 May 18;13:840369. doi: 10.3389/fgene.2022.840369. eCollection 2022.
PMID: 35664307
Huang Z, Liu L, Zhang J, Conde K, Phansalkar J, Li Z, Yao L, Xu Z, Wang W, Zhou J, Bi G, Wu F, Seeley RJ, Scott MM, Zhan C, Pang ZP, Liu J. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism.Sci Adv. 2022 Jun 10;8(23):eabn5345. doi: 10.1126/sciadv.abn5345. Epub 2022 Jun 8. PMID: 35675406
Liu JJ, Tsien RW, Pang ZP. Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity. Nat Neurosci. 2022. Epub 2022/01/05. doi: 10.1038/s41593-021-00984-5. PubMed PMID: 34980924.
2021
Robles DA, Boreland AJ, Pang ZP, Zahn JD. A Cerebral Organoid Connectivity Apparatus to Model Neuronal Tract Circuitry. Micromachines (Basel). 2021;12(12). Epub 2021/12/25. doi: 10.3390/mi12121574. PubMed PMID: 34945423; PMCID: PMC8706388.
Xu RJ, Boreland AJ, Li X, Erickson C, Jin M, Atkins C, Pang ZP, Daniels BP, Jiang P. Developing human pluripoent stem cell-based cerebral organioids with a controlleable microglia ratio for modeling brain development and pathology. Stem Cell Reports, 2021. Epub 2021/07/22 DOI:https://doi.org/10.1016/j.stemcr.2021.06.011
Pak C, Danko T, Mirabella VR, Wang J, Liu Y, Vangipuram M, Grieder S, Zhang X, Ward T, Huang YA, Jin K, Dexheimer P, Bardes E, Mitelpunkt A, Ma J, McLachlan M, Moore JC, Qu P, Purmann C, Dage JL, Swanson BJ, Urban AE, Aronow BJ, Pang ZP, Levinson DF, Wernig M, Sudhof TC. Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons. Proc Natl Acad Sci U S A. 2021;118(22). Epub 2021/05/27. doi: 10.1073/pnas.2025598118. PubMed PMID: 34035170.
McEwan S, Kwon H, Tahiri A, Shanmugarajah N, Cai W, Ke J, Huang T, Belton A, Singh B, Wang L, Pang ZP, Dirice E, Engel EA, El Ouaamari A. Deconstructing the Origins of Sexual Dimorphism in Sensory Modulation of Pancreatic beta Cells. Mol Metab. 2021:101260. Epub 2021/05/24. doi: 10.1016/j.molmet.2021.101260. PubMed PMID: 34023484.
Kozlova A, Butler RR, 3rd, Zhang S, Ujas T, Zhang H, Steidl S, Sanders AR, Pang ZP, Vezina P, Duan J. Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes. Neuropsychopharmacology. 2021. Epub 2021/05/20. doi: 10.1038/s41386-021-01027-0. PubMed PMID: 34007041.
2020
Zhao N, Yang X, Calvelli HR, Cao Y, Francis NL, Chmielowski RA, Joseph LB, Pang ZP, Uhrich KE, Baum J, Moghe PV. Antioxidant Nanoparticles for Concerted Inhibition of alpha-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation. Front Bioeng Biotechnol. 2020;8:112. Epub 2020/03/11. doi: 10.3389/fbioe.2020.00112. PubMed PMID: 32154238; PMCID: PMC7046761.
Hu P, Maita I, Phan ML, Gu E, Kwok C, Dieterich A, Gergues MM, Yohn CN, Wang Y, Zhou JN, Qi XR, Swaab DF, Pang ZP, Lucassen PJ, Roepke TA, Samuels BA. Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis. Transl Psychiatry. 2020;10(1):396. Epub 2020/11/13. doi: 10.1038/s41398-020-01070-3. PubMed PMID: 33177511; PMCID: PMC7658214.
Zhang S, Zhang H, Zhou Y, Miao M, Zhao S., Kozlova A, Shi J, Sanders AR, Wang G, Luo K, Sengupta S, West S, Qian S, Streit M, Avramopoulos D, Cowan CA, Chen M, Pang ZP, Gejman PV, He X, and Duan J. Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants, Science. 2020 Jul 31;369(6503):561-565. doi: 10.1126/science.aay3983.
Scarnati MS, Boreland AJ, Joel M, Hart RP, Pang ZP. Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol. Alcohol. 2020 Sep. 87:97-109. doi: 10.1016/j.alcohol.2020.05.004. Epub 2020 Jun 17.
Scarnati MS, Clarke SG, Pang ZP, Paradiso K. Presynaptic calcium channel open probability and calcium influx throughout the action potential. Fron Synaptic Neurosci, 2020 doi:10.3389/fnsyn.2020.00017
Hu P, Liu J, Maita I, Kwok C, Gu E, Gergues MM, Kelada F, Phan M, Zhou JN, Swaab DF, Pang ZP, Lucassen PJ, Roepke TA, Samuels BA. Chronic Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. J Neurosci. 2020 Feb 11. pii: 2410-19. doi: 10.1523/JNEUROSCI.2410-19.2020.
Fantuzzo JA, Robles DA, Mirabella VR, Hart RP, Pang ZP, Zahn JD. Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications, Lab-on-Chip, 2020. doi: 10.1039/c9lc01179j.
Zhao N, Yang X, Calvelli HR, Cao Y, Francis N, Chmielowski RA, Joseph LB, Pang ZP, Uhrich K, Baum J, Moghe PV. Antioxidant nanoparticles for concerted inhibition of alpha-synuclein fibrilization, and attenuation of microglial intracellular aggregation and activation, Front Bioeng Biotechnol. 2020 Feb 21;8:112. doi: 10.3389/fbioe.2020.00112. eCollection 2020.PMID: 32154238.
2019
Halikere A, Popova D, Scarnati M, Hamod A, Swerdel MR, Moores JC, Tischfield JA, Hart RP, and Pang ZP. Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. Mol Psychiatry 2019 doi: 10.1038/s41380-019-0507-0
Butler R, Kozlova A, Zhang H, Zhang S, Streit M, Sanders AR, Pang ZP, Gejman PV, Duan J. Human iPSC-derived microglia are genetically relevant to Alzheimer’s disease but not to schizophrenia, Mol Neuropsychiatry 2019, https://doi.org/10.1159/000501935
Francis N, Zhao N, Calvelli HR, Saini A, Gifford JJ, Wagner GC, Cohen RI, Pang ZP, Moghe PV. Peptide-based scaffolds for the culture and transplantation of human dopaminergic neurons. Tissue Eng Part A, 2019 Sep 20. doi: 10.1089/ten.TEA.2019.0094
Popova D, Desai N, Blendy J, Pang ZP. Synaptic regulation by OPRM1 variants in reward neurocircuitry. J Neurosci. 2019 May 20. pii: 2317-18. doi: 10.1523/JNEUROSCI.2317-18.2019. PMID: 31109961
Xu R, Brawner AT, Li S, Liu JJ, Kim H, Xue H, Pang ZP, Kim WY, Hart RP, Liu Y, Jiang P. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019 May 14. pii: S1934-5909(19)30163-8. doi: 10.1016/j.stem.2019.04.014.
Fantuzzo JA, Hart RP, Zahn JD, Pang ZP. Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. Dev Dyn. 2019 Jan;248(1):65-77. doi: 10.1002/dvdy.24665.
Scarnati MS, Halikere A, Pang ZP. Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. Alcohol. 2019 Feb;74:83-93. doi: 10.1016/j.alcohol.2018.03.008.
2018
Liu JJ, Mirabella VR, Pang ZP. Cell type- and pathway-specific synaptic regulation of orexin neurocircuitry. Brain Res. 2018 Oct 5. pii: S0006-8993(18)30507-9. doi: 10.1016/j.brainres.2018.10.003
McGowan H, Mirabella V, Hamod A, Kayakhanyan A, Mlynark N, Moore JC, Tischfield JA, Hart RP and Pang ZP. hsa-let-7c miRNA regulates synaptic and neuronal function in human neurons, Front Synaptic Neurosci.2018,10:19.doi:10.3389/fnsyn.2018.00019
Zhang S, Moy W, Zhang H, Leites C, McGowan H, Shi J, Sanders A, Pang ZP, Gejman PV and Duan J. Open Chromatin Dynamics Reveals Stage-specific Transcriptional Networks in hiPSC-based neurodevelopmental model, Stem Cell Research, 2018 2018 Mar 31;29:88-98. doi: 10.1016/j.scr.2018.03.014.
2017
Fantuzzo J, Mirabella V, Hamod A, Hart RP, Zahn J, Pang ZP. Intellicount: High-throughput quantification of synaptic protein puncta by machine learning, eNeuro, Nov/Dec, 4(6) e0219-17, 2017
Liu JJ, Bello N, Pang ZP. Synaptic regulation by leptin in defined lateral hypothalamus–ventral tegmental area neurocircuitry is energy-state responsive, J Neurosci, 37(49):11854-11866, 2017
Liu J, Conde K, Zhang P, Lilascharoen V, Lim BK, Seeley R, Zhu JJ, Scott MM, Pang ZP. Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon like peptide-1 in the paraventricular hypothalamus, Neuron, 96(4): 897-909, 2017.
Chemin J, Taiakina V, Monteil A, Piazza M, Guan W, Stephens RF, Kitmitto A, Pang ZP, Dolphin AC, Perez-Reyes E, Dieckmann T, Guillemette JG, Spafford JD. Calmodulin regulates Cav3 T-type channels at their gating brake. J Biol Chem; 292(49) 20010-20031, 2017.
Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King RA, Pang ZP, Xing J, Heiman GA, Tischfield JA. The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Mol Psychiatry; 00, 1-9, 2017.
Ong ZY, Liu JJ, Pang ZP, Grill HJ. Paraventricular Thalamic Control of Food Intake and Reward: Role of Glucagon-Like Peptide-1 Receptori signaling. Neuropsychopharmacology; 42: 2387-2397, 2017.
Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P and Duran J. Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci. Cell Stem Cell; 21: 1-14, 2017.
Joseph A. Fantuzzo JA, De Filippis L, McGowan H, Yang N, Ng YH, Halikere A, Liu JJ, Hart RP, Wernig M, Zahn JD and Pang ZP. μNeurocircuitry: establishing in vitro models of neurocircuits with human neurons, Technology; 5(2):87-95, 2017.
Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chagn Q, PangZP, Huganir RL, Zhu JJ. BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method. Genes Dev; 31(6): 537-552, 2017.
2016
Xue Y, Qian H, Hu J, Zhou B, Zhou Y, Hu X, Karakhanyan A, Pang ZP and Fu XD. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nat Neurosci, 19:807-815, 2016.
Liu J and Pang ZP. Glucagon like peptide-1 drives energy metabolism on the synaptic highway. FEBS Journal. Invited State-of-the-Art Review, 2016.
Hu P, Liu J, Yasrebi A, Gotthardt JD, Bello NT, Pang ZP and Roepke TA. Gq-protein-Coupled Membrane-Initiated Estrogen Signaling Rapidly Excites Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus in Female Mice.
Oni EN, Halikere A, Li G, Toro-Ramos AJ, Swerdel MR, Verpeut JL, Moore JC, Bello NT, Bierut LJ, Goate A, Tischfield JA, Pang ZP and Hart RP. Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. Sci Rep. 2016; 6:34341.
Nichola F, Bennett NK, Halikere A, Pang ZP and Moghe PV. Self-assembling peptide nanofiber scaffolds for 3-D reprogramming and transplantation of human pluripotent stem cell-derived neurons. ACS Biomater. Sci. Eng, 2016.
DeFilippis L, Halikere A, McGowan H, Moore JC, Tischfield JA, Hart RP and Pang ZP. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Molecular Brain 9:51, 2016.
Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP and Moghe PV. Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nature Commun, 7:10862, 2016.
2015
Shreyas S, Liu JJ, Pasquale N, Lai J, McGowan H, Pang ZP and Lee KB. Hybrid upconversion nanomaterials for optogenetic neuronal control. Nanoscale, 7: 16571-16577, 2015.
DeFilippis L, Sudhof TC and Pang ZP. Harness the power of endogenous neural stem cells by biomaterials to treat spinal cord injury. Life Sciences China, November; 58: 1167-1168, 2015.
McGowan H and Pang ZP. Regulatory functions and pathological relevance of the MECP2 3’UTR in the central nervous system. Cell Regen (Lond), Oct 28; 4:9, 2015.
Wang XF, Liu JJ, Xia J, Liu J, Mirabella V and Pang ZP. Endogenous glucagon-like peptide-1 suppresses high-fat food intake by reducing synaptic drive onto mesolimbic dipamine neurons. Cell Report, 12, 1-8, 2015.
Liu JJ, Mukherjee D, Haritan D, Ignatowska-Jankowska B, Liu J, Citri A and Pang ZP. High on food: the interaction between the neural circuits for feeding and for reward. Front Biol, 10(2): 165-176, 2015.
2014
Wang Y, Ali Y, Lim CY, Hong W, Pang ZP and Han W. Insulin-stimulated leptin secretion requires calcium and Pl3K/Akt activation. Biochem J, 458(3): 491-8, 2014.
Wei S, Soh SL, Xia J, Ong WY, Pang ZP and Han W. Motor neuropathy-associated mutation impairs Seipin functions in neurotransmission. J Neurochem, 129(2): 328-38, 2014.
2013
Pertsinidis A, Mukherjee K, Sharma M, Pang ZP, Park SR, Zhang Y, Brunger AT, Sudhof TC and Chu S. Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proceedings of the National Academy of Sciences of the United States of America, 110(30), E2812–2820, 2013.
Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T and Südhof TC. Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. The EMBO journal, 32(1), 159–171, 2013.
Guo J, Qiu W, Soh SLY, Wei S, Radda GK, Ong WY, Pang ZP and Han W. Motor neuron degeneration in a mouse model of seipinopathy. Cell death & disease, 4, e535. doi:10.1038/cddis.2013.64, 2013.
Wei S, Soh SLY, Qiu W, Yang W, Seah CJY, Guo J, Ong WY, Pang ZP and Han W. Seipin regulates excitatory synaptic transmission in cortical neurons. Journal of neurochemistry, 124(4), 478–489. doi:10.1111/jnc.12099, 2013.
2012
Xu W, Morishita W, Buckmaster PS, Pang ZP, Malenka RC and Südhof TC. Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron, 73:990-1001, 2012.
Pang ZP and Han W. Regulation of syanptic functions in central nervous system by endocrine hormones and the maintenance of energy homeostais. Biosci Rep. 2012.
2011
Citri A, Pang ZP, Wernig M, Südhof TC and Malenka RC*. Comprehensive qPCR profiling of gene expression in single neuronal cells, Nature Protocols, 7:118-127, 2012.
Marro S, Pang ZP, Yang N, Tsai MC, Qu K, change HY, Südhof TC and Wernig M. Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell, 9:374-382, 2011.
Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC and Wernig M. Transcription factor-mediated induction of neurons from somatic and pluripotent human cells. Nature, 476(7359) :220-223, 2011.
Pang ZP, Bacaj T, Yang XF, Zhou P and Südhof TC. Doc2 supports spontaneous synaptic transmission by a Ca2+-independent mechanism. Neuron, 70:244-251, 2011.
Deng P, Pang ZP, Lei ZG, Shikano S, Xiong Q, Harvey B, London B, Wang Y, Li M and Xu Z. Up-regulation of A-type Potassium Currents Protects Neurons against Cerebral Ischemia. Journal of Cerebral Blood Flow & Metabolism, 31(9):1823-1835, 2011.
Yang N, Ng YH, Pang ZP, Südhof TC and Wernig M. Induced Neuronal Cells: how to make and define a neuron. Cell Stem Cell, 9:517-525, 2011.
2010
Pang ZP, Xu W, Cao P and Südhof TC. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. Journal of Biological Chemistry, 285: 33930-33939, 2010.
Pang ZP, Cao P, Xu W and Südhof TC. Calmodulin controls synaptic strength via presynaptic activation of CaM Kinase II. Journal of Neuroscience, 30:4132-4142, 2010.
Pang ZP and Südhof TC. Cell biology of Ca2+-triggered exocytosis. Current Opinion in Cell Biology, 22:496-505, 2010.
Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC and Wernig M. Direct conversion of fibroblasts to functional neurons by defined transcription factors. Nature, 463:1035-1041, 2010.
Yang XF, Kaeser-Woo YJ, Pang ZP, Xu W and Südhof TC. Complexin clamps fusion by blocking a secondary Ca2+-sensor via its accessory alpha-helix. Neuron, 68:907-920, 2010.
Sun T, Wu X, Xu J, McNeil B, Pang ZP, Yang W, Bai L, Qadri S, Molkentin J, Yue D and Wu LG. The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses. Journal of Neuroscience, 30:11838-11847, 2010.
Shin OK, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik S, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund and Südhof TC. Munc13 C2B domain is an activity-dependent Ca2+-regulator of synaptic exocytosis. Nature Structural and Molecular Biology, 17:280-288, 2010.
Bacaj T, Pang ZP and Südhof TC. Testing the SNARE/SM protein model of membrane fusion. Proc Natl Acad Sci USA, 107:22365-22366, 2010.
Before 2009
Maximov A, Tang J, Yang X, Pang ZP, Südhof TC. Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science, 323:516-521, 2009.
Xu J, Pang ZP, Shin O-H and Südhof TC. Synaptotagmin-1 functions as Ca2+-sensor for spontaneous synaptic miniature release. Nature Neuroscience, 12:759-766, 2009.
Deng P, Pang ZP, Lei Z and Xu ZC. Excitatory roles of protein kinase C in striatal cholinergic interneurons. Journal of Neurophysiology, 102:2453-2461, 2009.
Liang R, Pang ZP, Deng P and Xu ZC. Transient enhancement of inhibitory synaptic transmission in hippocampal CA1 pyramidal neurons after cerebral ischemia. Neuroscience, 160:412-418, 2009.
Sun J, Pang ZP, Qin D, Fahim AT, Adachi R and Südhof TC. A dual-Ca2+-sensor model for the neurotransmitter release in a central synapse. Nature, 450:676-682, 2007.
Pang ZP, Shin OK, Meyer A, Rosenmund C and Südhof TC. A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent SNARE-complex binding in synaptic exocytosis. Journal of Neuroscience, 26:12556-12565, 2006.
Wu H, Xu J, Pang ZP, Ge W, Kim KJ, Blanchi B, Chen C, Südhof TC and Sun YE. Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proceedings of the National Academy of Sciences of the USA, 104:13821-13826, 2007.
Pang ZP, Melicoff E, Padgett D, Liu Y, Teich A, Dickey B, Lin W, Adachi R and Südhof TC. Synaptotagmin-2 is essential for survival and contributes to Ca2+-triggering of neurotransmitter release in central and neuromuscular synapses. Journal of Neuroscience, 26:13493-13504, 2006.
Pang ZP, Sun J, Rizo J, Maximov A, Südhof TC. Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO Journal, 25:2039-2050, 2006. See analysis of supplementary figure and corrected supplementary information.
Nagy G, Kim JH, Pang ZP, Matti U, Rettig J, Südhof TC, Sorensen JB. Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. Journal of Neuroscience, 26:632-643, 2006.
Fan Y, Zou B, Ruan Y, Pang ZP and Xu ZC. In vivo demonstration of a late depolarizing postsynaptic potential in CA1 pyramidal neurons. Journal of Neurophysiology, 93:1326-1335, 2005.
Deng P, Pang ZP, Zhang Y and Xu ZC. Increase of delayed rectifier potassium currents in large aspiny neurons in the neostriatum following transient forebrain ischemia. Neuroscience, 2005, 131:135-146.
Wu MF, Pang ZP, Zhuo M and Xu ZC. Prolonged membrane potential depolarization in cingulate pyramidal cells after digit amputation in adult rats. Molecular Pain, 1:23, 2005.
Deng P, Pang ZP, Zhang Y and Xu ZC. Developmental changes of transient potassium currents in large aspiny neurons in the neostriatum. Developmental Brain Research, 153:97-107, 2004.
Pang ZP, Ling GY, Gajendiran M and Xu ZC. Asymmetric changes of excitatory transmission in spiny neurons following transient forebrain ischemia after dopamine depletion. Neuroscience, 114:317-326, 2002.
Pang ZP, Deng P, Ruan YW and Xu ZC. Depression of fast excitatory synaptic transmission in striatal large aspiny neurons after transient forebrain ischemia. Journal of Neuroscience, 22:10948-10957, 2002.
Gajendiran M, Ling GY, Pang ZP and Xu ZC. Differential changes of synaptic transmission in spiny neurons of rat neostriatum following transient forebrain ischemia. Neuroscience, 105:139-152, 2001.
Pang ZP, Ling GY, Gajendiran M and Xu ZC. Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation. Neuroscience Letter, 308:201-205, 2001.
Kiyosawa A, Katsurabayashi S, Akaike N, Pang ZP and Akaike N. Nicotine facilitates glycine release in the rat spinal dorsal horn. Journal of Physiology (Lond), 536:101-110, 2001.
Xu TL, Pang ZP, Li JS and Akaike N. 5-HT potentiation of the GABAA response in the rat sacral dorsal commissural neurons. British Journal of Pharmacology, 124:779-787, 1998.
Wang DS, Xu TL, Pang ZP, Li JS and Akaike N. Taurine-activated chloride currents in rat sacral dorsal commissural neurons. Brain Research, 792:41-47, 1998.
Pang Lab 